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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK1 All Species: 29.39
Human Site: S286 Identified Species: 46.19
UniProt: O14757 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14757 NP_001107593.1 476 54420 S286 T S G G V S E S P S G F S K H
Chimpanzee Pan troglodytes XP_001145968 476 54387 S286 T S G G V S E S P S G F S K H
Rhesus Macaque Macaca mulatta XP_001111357 476 54432 S286 T S G G V S E S P S G F S K H
Dog Lupus familis XP_852191 460 52810 S270 T S G G V S E S P S G F S K H
Cat Felis silvestris
Mouse Mus musculus O35280 476 54363 S286 T S G G M S E S S S G F S K H
Rat Rattus norvegicus Q91ZN7 476 54410 S286 T S G G M S E S S S G F S K H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513209 476 53924 S286 S S G G L A D S P G G F G K H
Chicken Gallus gallus Q8AYC9 476 53830 S286 S S G G V T E S P G A L P K H
Frog Xenopus laevis Q6DE87 474 53957 D285 V I S G G S S D S S V L C K Q
Zebra Danio Brachydanio rerio NP_956487 410 46756 R237 T P A A K I Q R A D S E L R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61661 512 57815 A298 D L V D S A A A L E I C S P K
Honey Bee Apis mellifera XP_623436 467 53927 D284 Y I R P D E T D S R Q I I E D
Nematode Worm Caenorhab. elegans Q9N3Z3 503 56917 N306 R P L K R A R N N D E N I T C
Sea Urchin Strong. purpuratus NP_001091925 468 52554 R286 P N T G S M K R V C T G N D L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84VQ3 439 49610 R247 G A K N L I V R I L D P N P M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.3 93.2 N.A. 93.2 94.3 N.A. 89.9 84.4 77.7 56.9 N.A. 46 45.5 32 57.9
Protein Similarity: 100 100 99.7 95.1 N.A. 97 97.2 N.A. 95.3 91.5 86.7 71 N.A. 62.8 63.8 48.7 73.3
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. 60 60 26.6 6.6 N.A. 6.6 0 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 86.6 73.3 26.6 20 N.A. 20 6.6 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 32.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 52.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 7 0 20 7 7 7 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 7 7 0 7 % C
% Asp: 7 0 0 7 7 0 7 14 0 14 7 0 0 7 7 % D
% Glu: 0 0 0 0 0 7 47 0 0 7 7 7 0 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 47 0 0 0 % F
% Gly: 7 0 54 67 7 0 0 0 0 14 47 7 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 54 % H
% Ile: 0 14 0 0 0 14 0 0 7 0 7 7 14 0 0 % I
% Lys: 0 0 7 7 7 0 7 0 0 0 0 0 0 60 7 % K
% Leu: 0 7 7 0 14 0 0 0 7 7 0 14 7 0 7 % L
% Met: 0 0 0 0 14 7 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 7 0 7 0 0 0 7 7 0 0 7 14 0 0 % N
% Pro: 7 14 0 7 0 0 0 0 40 0 0 7 7 14 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 7 0 0 0 7 % Q
% Arg: 7 0 7 0 7 0 7 20 0 7 0 0 0 7 7 % R
% Ser: 14 54 7 0 14 47 7 54 27 47 7 0 47 0 0 % S
% Thr: 47 0 7 0 0 7 7 0 0 0 7 0 0 7 0 % T
% Val: 7 0 7 0 34 0 7 0 7 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _